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1

Race, Religion, and Opposition to Same-Sex Marriage

Darren E. Sherkat, Kylan Mattias De Vries, Stacia Creek

Journal:

Social Science Quarterly

Année:

2010

Langue:

english

Fichier:

PDF, 206 KB

english, 2010

2

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

Creek, Darren J., Jankevics, Andris, Breitling, Rainer, Watson, David G., Barrett, Michael P., Burgess, Karl E. V.

Journal:

Analytical Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 3.25 MB

english, 2011

3

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks

Chokkathukalam, Achuthanunni, Kim, Dong-Hyun, Barrett, Michael P, Breitling, Rainer, Creek, Darren J

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 3.53 MB

english, 2014

4

Metabolomics continues to expand: highlights from the 2015 metabolomics conference

Fiehn, Oliver, Putri, Sastia P., Saito, Kazuki, Salek, Reza M., Creek, Darren J.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 655 KB

english, 2015

5

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Steketee, Pieter C., Vincent, Isabel M., Achcar, Fiona, Giordani, Federica, Kim, Dong-Hyun, Creek, Darren J., Freund, Yvonne, Jacobs, Robert, Rattigan, Kevin, Horn, David, Field, Mark C., MacLeod, Ann

Journal:

PLoS Neglected Tropical Diseases

Année:

2018

Langue:

english

Fichier:

PDF, 10.46 MB

english, 2018

6

Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt

Darren J. Creek, Francis C.K. Chiu, Richard J. Prankerd, Susan A. Charman, William N. Charman

Journal:

Journal of Pharmaceutical Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 173 KB

english, 2005

7

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials

Darren J. Creek, William N. Charman, Francis C.K. Chiu, Richard J. Prankerd, Kevin J. McCullough, Yuxiang Dong, Jonathan L. Vennerstrom, Susan A. Charman

Journal:

Journal of Pharmaceutical Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 207 KB

english, 2007

8

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity

Xiaofang Wang, Darren J. Creek, Charles E. Schiaffo, Yuxiang Dong, Jacques Chollet, Christian Scheurer, Sergio Wittlin, Susan A. Charman, Patrick H. Dussault, James K. Wood, Jonathan L. Vennerstrom

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 323 KB

english, 2009

9

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Maniyan Padmanilayam, Bernard Scorneaux, Yuxiang Dong, Jacques Chollet, Hugues Matile, Susan A. Charman, Darren J. Creek, William N. Charman, Josefina Santo Tomas, Christian Scheurer, Sergio Wittlin,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 127 KB

english, 2006

10

Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes

Darren J. Creek, David K. Chalmers, William N. Charman, Brian J. Duke

Journal:

Journal of Molecular Graphics and Modelling

Année:

2008

Langue:

english

Fichier:

PDF, 597 KB

english, 2008

11

Pathos: A web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry

David P. Leader, Karl Burgess, Darren Creek, Michael P. Barrett

Journal:

Rapid Communications in Mass Spectrometry

Année:

2011

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2011

12

Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry

Karl Burgess, Darren Creek, Paul Dewsbury, Ken Cook, Michael P. Barrett

Journal:

Rapid Communications in Mass Spectrometry

Année:

2011

Langue:

english

Fichier:

PDF, 593 KB

english, 2011

13

Metabolomic analysis of trypanosomatid protozoa

Darren J. Creek, Jana Anderson, Malcolm J. McConville, Michael P. Barrett

Journal:

Molecular and Biochemical Parasitology

Année:

2012

Langue:

english

Fichier:

PDF, 565 KB

english, 2012

14

Spiro- and Dispiro-1,2-dioxolanes: Contribution of Iron(II)-Mediated One-Electron vs Two-Electron Reduction to the Activity of Antimalarial Peroxides

Wang, Xiaofang, Dong, Yuxiang, Wittlin, Sergio, Creek, Darren, Chollet, Jacques, Charman, Susan A., Santo Tomas, Josefina, Scheurer, Christian, Snyder, Christopher, Vennerstrom, Jonathan L.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 123 KB

english, 2007

15

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

Warwick B. Dunn, Alexander Erban, Ralf J. M. Weber, Darren J. Creek…

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 737 KB

english, 2013

16

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

Klonis, Nectarios, Creek, Darren J, Tilley, Leann

Journal:

Current Opinion in Microbiology

Année:

2013

Langue:

english

Fichier:

PDF, 630 KB

english, 2013

17

Metabolite identification: are you sure? And how do your peers gauge your confidence?

Creek, Darren J., Dunn, Warwick B., Fiehn, Oliver, Griffin, Julian L., Hall, Robert D., Lei, Zhentian, Mistrik, Robert, Neumann, Steffen, Schymanski, Emma L., Sumner, Lloyd W., Trengove, Robert, Wolfe

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 143 KB

english, 2014

18

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

Creek, Darren J., Chokkathukalam, Achuthanunni, Jankevics, Andris, Burgess, Karl E. V., Breitling, Rainer, Barrett, Michael P.

Journal:

Analytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 347 KB

english, 2012

19

Supporting the industry sector of the metabolomics community: the remit of the Metabolomics Society’s Industry Engagement Task Group

Viant, Mark R., Bearden, Daniel W., Creek, Darren J., Fiehn, Oliver, Robertson, Donald G.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 135 KB

english, 2014

20

Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine

Zhang, Tong, Creek, Darren J., Barrett, Michael P., Blackburn, Gavin, Watson, David G.

Journal:

Analytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 3.31 MB

english, 2012

21

Stable isotope labeled metabolomics improves identification of novel metabolites and pathways

Creek, Darren J

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 621 KB

english, 2013

22

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii

Limenitakis, Julien, Oppenheim, Rebecca D., Creek, Darren J., Foth, Bernardo J., Barrett, Michael P., Soldati-Favre, Dominique

Journal:

Molecular Microbiology

Année:

2013

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2013

23

Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool

Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P., Robello, Carlos

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2015

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2015

24

Determination of antiprotozoal drug mechanisms by metabolomics approaches

CREEK, DARREN J., BARRETT, MICHAEL P.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 348 KB

english, 2014

25

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

Oppenheim, Rebecca D., Creek, Darren J., Macrae, James I., Modrzynska, Katarzyna K., Pino, Paco, Limenitakis, Julien, Polonais, Valerie, Seeber, Frank, Barrett, Michael P., Billker, Oliver, McConville

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2014

26

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

Vincent, Isabel M., Creek, Darren J., Burgess, Karl, Woods, Debra J., Burchmore, Richard J. S., Barrett, Michael P., Bates, Paul Andrew

Journal:

PLoS Neglected Tropical Diseases

Année:

2012

Langue:

english

Fichier:

PDF, 785 KB

english, 2012

27

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

Creek, Darren J., Mazet, Muriel, Achcar, Fiona, Anderson, Jana, Kim, Dong-Hyun, Kamour, Ruwida, Morand, Pauline, Millerioux, Yoann, Biran, Marc, Kerkhoven, Eduard J., Chokkathukalam, Achuthanunni, Wei

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2015

28

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P., Robello, Carlos, Pollastri, Michael P.

Journal:

PLoS Neglected Tropical Diseases

Année:

2014

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2014

29

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

Vincent, Isabel M., Creek, Darren, Watson, David G., Kamleh, Mohammed A., Woods, Debra J., Wong, Pui Ee, Burchmore, Richard J. S., Barrett, Michael P., Parsons, Marilyn

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 714 KB

english, 2010

30

What role can metabolomics play in the discovery and development of new medicines for infectious diseases?

Kim, Dong-Hyun, Creek, Darren J

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2015

31

Metabolic dysregulation induced in Plasmodium falciparum by dihydroartemisinin and other front line antimalarial drugs

Cobbold, Simon A., Chua, Hwa H., Nijagal, Brunda, Creek, Darren J., Ralph, Stuart A., McConville, Malcolm J.

Journal:

The Journal of Infectious Diseases

Année:

2015

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2015

32

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

Tran, Thien B, Cheah, Soon-Ee, Yu, Heidi H, Bergen, Phillip J, Nation, Roger L, Creek, Darren J, Purcell, Anthony, Forrest, Alan, Doi, Yohei, Song, Jiangning, Velkov, Tony, Li, Jian

Journal:

The Journal of Antibiotics

Année:

2015

Langue:

english

Fichier:

PDF, 883 KB

english, 2015

33

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl)thiazol-2-ylamino)phenol (SKI-II)

Aurelio, Luigi, Scullino, Carmen, Pitman, Melissa, Sexton, Anna, Oliver, Vitoria, Davies, Lorena, Rebello, Richard, Furic, Luc, Creek, Darren John, Pitson, Stuart, Flynn, Bernard L.

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2016

34

A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum

Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2016

35

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis

Bhuiyan, Md Saruar, Ellett, Felix, Murray, Gerald L., Kostoulias, Xenia, Cerqueira, Gustavo M., Schulze, Keith E., Mahamad Maifiah, Mohd Hafidz, Li, Jian, Creek, Darren J., Lieschke, Graham J., Peleg,

Journal:

Proceedings of the National Academy of Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2016

36

Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria

Tchaparian, Eskouhie, Sambol, Nancy C., Arinaitwe, Emmanuel, McCormack, Shelley A., Bigira, Victor, Wanzira, Humphrey, Muhindo, Mary, Creek, Darren J., Sukumar, Nitin, Blessborn, Daniel, Tappero, Jord

Journal:

The Journal of Infectious Diseases

Année:

2016

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2016

37

Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action

Creek, Darren J, Chua, Hwa H, Cobbold, Simon A, Nijagal, Brunda, Macrae, James I, Dickerman, Benjamin K., Gilson, Paul R., Ralph, Stuart A, McConville, Malcolm J

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 9.32 MB

english, 2016

38

Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes

Srivastava, Anubhav, Evans, Krystal J., Sexton, Anna E., Schofield, Louis, Creek, Darren J.

Journal:

Journal of Proteome Research

Année:

2017

Langue:

english

Fichier:

PDF, 3.73 MB

english, 2017

39

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

Maifiah, Mohd Hafidz Mahamad, Creek, Darren J., Nation, Roger L., Forrest, Alan, Tsuji, Brian T., Velkov, Tony, Li, Jian

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2017

40

Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant Plasmodium falciparum

Siddiqui, Ghizal, Srivastava, Anubhav, Russell, Adrian S., Creek, Darren J.

Journal:

The Journal of Infectious Diseases

Année:

2017

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2017

41

Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia

Murray, Gerald L., Tsyganov, Kirill, Kostoulias, Xenia P., Bulach, Dieter M., Powell, David, Creek, Darren J., Boyce, John D., Paulsen, Ian T., Peleg, Anton Y.

Journal:

The Journal of Infectious Diseases

Année:

2017

Langue:

english

Fichier:

PDF, 3.11 MB

english, 2017

42

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

Alzahrani, Khalid J.H., Ali, Juma A.M., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A., Creek, Darren J., Barrett, Michael P., de Koning, Harry P.

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Année:

2017

Langue:

english

Fichier:

PDF, 979 KB

english, 2017

43

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles

Wang, Miaoyi, Siddiqui, Ghizal, Gustafsson, Ove J. R., Käkinen, Aleksandr, Javed, Ibrahim, Voelcker, Nicolas H., Creek, Darren J., Ke, Pu Chun, Davis, Thomas P.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2017

44

Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity

Giannangelo, Carlo, Stingelin, Lukas, Yang, Tuo, Tilley, Leann, Charman, Susan A., Creek, Darren J.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2017

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2017

45

A High Parasite Density Environment Induces Transcriptional Changes and Cell Death in Plasmodium falciparum Blood Stages

Chou, Evelyn S., Abidi, Sabia Z., Teye, Marian, Leliwa-Sytek, Aleksandra, Rask, Thomas S., Cobbold, Simon A., Tonkin-Hill, Gerry Q., Subramaniam, Krishanthi S., Sexton, Anna E., Creek, Darren J., Dail

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2017

46

NormalizeMets: assessing, selecting and implementing statistical methods for normalizing metabolomics data

De Livera, Alysha M., Olshansky, Gavriel, Simpson, Julie A., Creek, Darren J.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2018

47

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

Wang, Miaoyi, Gustafsson, Ove Johan Ragnar, Siddiqui, Ghizal, Javed, Ibrahim, Kelly, Hannah G, Blin, Thomas, Yin, Hong, Kent, Stephen J., Creek, Darren J, Kempe, Kristian, Ke, Pu Chun, Davis, Thomas

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.37 MB

english, 2018

48

Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa

Han, Mei-Ling, Zhu, Yan, Creek, Darren J., Lin, Yu-Wei, Anderson, Dovile, Shen, Hsin-Hui, Tsuji, Brian, Gutu, Alina D., Moskowitz, Samuel M., Velkov, Tony, Li, Jian

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2018

Langue:

english

Fichier:

PDF, 5.72 MB

english, 2018

49

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

Srivastava, Anubhav, Creek, Darren J., Evans, Krystal J., De Souza, David, Schofield, Louis, Müller, Sylke, Barrett, Michael P., McConville, Malcolm J., Waters, Andrew P., Kazura, James W.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2015

50

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

Tjhin, Erick T., Spry, Christina, Sewell, Alan L., Hoegl, Annabelle, Barnard, Leanne, Sexton, Anna E., Siddiqui, Ghizal, Howieson, Vanessa M., Maier, Alexander G., Creek, Darren J., Strauss, Erick, Ma

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 6.64 MB

english, 2018